Faculty of Medicine in Hradec Králové started its educational activities on November 25, 1945, as the first university faculty in East Bohemia. Initially, the Hradec Králové faculty was established as a part of the Prague Faculty of Medicine. Due to their co-operation and assistance, it was immediately possible to establish both high-quality teaching staff and an effective departmental structure in Hradec Králové.

To date, the studies have almost 10 000 general and dentists doctors.